Compared to Arch(-based): Accesing the latest packages. It’s not impossible, especially if you go for Debian testing repos, but it’s definitely extra work.

Compared to special-purpose distros (i.e. gaming, portable, high security/privacy, pen-testing): Whatever their special purpose is will usually be harder to achieve.

Compared to huge corpo distros (SUSE/Fedora and derivatives): Ease of more intricate setups and maybe some security testing.

Compared to Ubuntu: Paying a corporation to not withhold security patches from you.